Publications

Click here for our latest publications https://www.ncbi.nlm.nih.gov/sites/myncbi/1BWtyjhHuenkt/bibliography/49301414/public/?sort=date&direction=descending

• Putra M, Rao NS, Gardner C, Liu G, Trommater J, Bunney M, Gage M, Bassuk AG, Hefti M, Lee G, Thippeswamy T. Enhanced Fyn-tau and NR2B-PSD95 interactions in epileptic foci in experimental models and human epilepsy. Brain Commun. 2024;6(5):fcae327. doi: 10.1093/braincomms/fcae327. eCollection 2024. PubMed PMID: 39355003; PubMed Central PMCID: PMC11444080.
• Putra M, Vasanthi SS, Rao NS, Meyer C, Otterloo MV, Thangi L, Thedens DR, Kannurpatti SS, Thippeswamy T. Inhibiting iNOS with 1400W Reduces Soman (GD)-induced Ferroptosis in Long-term Epilepsy Associated Neuropathology: Structural and Functional MRI in correlations with neurobehavior and brain pathology. J Pharmacol Exp Ther. 2023 Dec 21;. doi: 10.1124/jpet.123.001929. [Epub ahead of print] PubMed PMID: 38129129.
• Meyer C, Grego E, S Vasanthi S, Rao NS, Massey N, Holtkamp C, Huss J, Showman L, Narasimhan B, Thippeswamy T. The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity. Antioxidants (Basel). 2023 Nov 30;12(12). doi: 10.3390/antiox12122061. PubMed PMID: 38136181; PubMed Central PMCID: PMC10740988.
• Vasanthi SS, Massey N, Nair SN, Mochel JP, Showman L, Thippeswamy T. Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare. Front Vet Sci. 2023;10:1297221. doi: 10.3389/fvets.2023.1297221. eCollection 2023. PubMed PMID: 38026620; PubMed Central PMCID: PMC10666625.
• Rao NS, Putra M, Meyer C, Almanza A, Thippeswamy T. The effects of Src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy. Front Mol Neurosci. 2023;16:1294514. doi: 10.3389/fnmol.2023.1294514. eCollection 2023. PubMed PMID: 38025259; PubMed Central PMCID: PMC10665569.
• Vasanthi SS, Rao NS, Samidurai M, Massey N, Meyer C, Gage M, Kharate M, Almanza A, Wachter L, Mafuta C, Trevino L, Carlo AM, Bryant E, Corson BE, Wohlgemuth M, Ostrander M, Showman L, Wang C, Thippeswamy T. Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy. J Neuroinflammation. 2023 Jul 12;20(1):163. doi: 10.1186/s12974-023-02847-1. PubMed PMID: 37438764; PubMed Central PMCID: PMC10337207.
• Meyer C, Rao NS, Vasanthi SS, Pereira B, Gage M, Putra M, Holtkamp C, Huss J, Thippeswamy T. Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity. Front Cell Neurosci. 2023;17:1195843. doi: 10.3389/fncel.2023.1195843. eCollection 2023. PubMed PMID: 37416507; PubMed Central PMCID: PMC10320212.
• Gage M, Vasanthi SS, Meyer CM, Rao NS, Thedens DR, Kannurpatti SS, Thippeswamy T. Sex-based structural and functional MRI outcomes in the rat brain after soman (GD) exposure-induced status epilepticus. Epilepsia Open. 2023 Jun;8(2):399-410. doi: 10.1002/epi4.12701. Epub 2023 Feb 6. PubMed PMID: 36718979; PubMed Central PMCID: PMC10235578.
• Vasanthi SS, Rao NS, Samidurai M, Massey N, Meyer C, Gage M, Kharate M, Almanza A, Wachter L, Mafuta C, Trevino L, Carlo AM, Bryant E, Corson BE, Wohlgemuth M, Ostrander M, Wang C, Thippeswamy T. Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy. Res Sq. 2023 May 8;. doi: 10.21203/rs.3.rs-2883247/v1. PubMed PMID: 37214912; PubMed Central PMCID: PMC10197763.
• Massey N, Vasanthi SS, Samidurai M, Gage M, Rao N, Meyer C, Thippeswamy T. 1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model. Front Mol Neurosci. 2023;16:1125934. doi: 10.3389/fnmol.2023.1125934. eCollection 2023. PubMed PMID: 37008784; PubMed Central PMCID: PMC10064070.
• Gage M, Vinithakumari AA, Mooyottu S, Thippeswamy T. Gut dysbiosis following organophosphate, diisopropylfluorophosphate (DFP), intoxication and saracatinib oral administration. Front Microbiomes. 2022;1. doi: 10.3389/frmbi.2022.1006078. Epub 2022 Oct 20. PubMed PMID: 37304619; PubMed Central PMCID: PMC10256240.
• Rao NS, Meyer C, Vasanthi SS, Massey N, Samidurai M, Gage M, Putra M, Almanza AN, Wachter L, Thippeswamy T. DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons. Front Cell Dev Biol. 2022;10:895092. doi: 10.3389/fcell.2022.895092. eCollection 2022. PubMed PMID: 35620057; PubMed Central PMCID: PMC9127803.
• Gage M, Gard M, Thippeswamy T. Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy. Front Cell Dev Biol. 2022;10:867949. doi: 10.3389/fcell.2022.867949. eCollection 2022. PubMed PMID: 35372361; PubMed Central PMCID: PMC8966428.
• Gage M, Rao NS, Samidurai M, Putra M, Vasanthi SS, Meyer C, Wang C, Thippeswamy T. Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology. Front Cell Neurosci. 2021;15:798247. doi: 10.3389/fncel.2021.798247. eCollection 2021. PubMed PMID: 35197823; PubMed Central PMCID: PMC8859837.
• Gage M, Putra M, Wachter L, Dishman K, Gard M, Gomez-Estrada C, Thippeswamy T. Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress. Antioxidants (Basel). 2021 Dec 28;11(1). doi: 10.3390/antiox11010061. PubMed PMID: 35052568; PubMed Central PMCID: PMC8773289.
• Gage M, Putra M, Gomez-Estrada C, Golden M, Wachter L, Gard M, Thippeswamy T. Differential Impact of Severity and Duration of Status Epilepticus, Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model. Front Cell Neurosci. 2021;15:772868. doi: 10.3389/fncel.2021.772868. eCollection 2021. PubMed PMID: 34720886; PubMed Central PMCID: PMC8555467.
• Sharma S, Carlson S, Gregory-Flores A, Hinojo-Perez A, Olson A, Thippeswamy T. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy. Neurobiol Dis. 2021 Aug;156:105410. doi: 10.1016/j.nbd.2021.105410. Epub 2021 Jun 1. PubMed PMID: 34087381; PubMed Central PMCID: PMC8325782.
• Tse K, Beamer E, Simpson D, Beynon RJ, Sills GJ, Thippeswamy T. The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles. Front Neurol. 2021;12:625017. doi: 10.3389/fneur.2021.625017. eCollection 2021. PubMed PMID: 34322075; PubMed Central PMCID: PMC8312573.
• Gage MC, Thippeswamy T. Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases. CNS Drugs. 2021 Jan;35(1):1-20. doi: 10.1007/s40263-020-00787-5. Epub 2021 Jan 30. Review. PubMed PMID: 33515429; PubMed Central PMCID: PMC7893831.
• Putra M, Puttachary S, Liu G, Lee G, Thippeswamy T. Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis. Front Cell Neurosci. 2020;14:592374. doi: 10.3389/fncel.2020.592374. eCollection 2020. PubMed PMID: 33363455; PubMed Central PMCID: PMC7752812.
• Putra M, Gage M, Sharma S, Gardner C, Gasser G, Anantharam V, Thippeswamy T. Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model. Ann N Y Acad Sci. 2020 Nov;1479(1):75-93. doi: 10.1111/nyas.14314. Epub 2020 Feb 10. PubMed PMID: 32037612; PubMed Central PMCID: PMC7415478.
• Gage M, Golden M, Putra M, Sharma S, Thippeswamy T. Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity. Ann N Y Acad Sci. 2020 Nov;1479(1):44-64. doi: 10.1111/nyas.14315. Epub 2020 Feb 23. PubMed PMID: 32090337; PubMed Central PMCID: PMC7483197.
• Putra M, Sharma S, Gage M, Gasser G, Hinojo-Perez A, Olson A, Gregory-Flores A, Puttachary S, Wang C, Anantharam V, Thippeswamy T. Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model. Neurobiol Dis. 2020 Jan;133:104443. doi: 10.1016/j.nbd.2019.03.031. Epub 2019 Mar 30. PubMed PMID: 30940499; PubMed Central PMCID: PMC6768773.
• Sharma S, Puttachary S, Thippeswamy T. Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy. J Neurosci Res. 2019 Nov;97(11):1363-1377. doi: 10.1002/jnr.24205. Epub 2017 Dec 12. Review. PubMed PMID: 29230865; PubMed Central PMCID: PMC6035106.
• Tse K, Hammond D, Simpson D, Beynon RJ, Beamer E, Tymianski M, Salter MW, Sills GJ, Thippeswamy T. The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis. J Neurosci Res. 2019 Nov;97(11):1378-1392. doi: 10.1002/jnr.24441. Epub 2019 May 15. PubMed PMID: 31090233; PubMed Central PMCID: PMC6752963.
• Thippeswamy T. In Focus: Disease promoters during epileptogenesis. J Neurosci Res. 2019 Nov;97(11):1333-1334. doi: 10.1002/jnr.24518. Epub 2019 Aug 21. PubMed PMID: 31433067; PubMed Central PMCID: PMC6753052.
• Staunton CA, Barrett-Jolley R, Djouhri L, Thippeswamy T. Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. Exp Physiol. 2018 Apr 1;103(4):535-544. doi: 10.1113/EP086764. Epub 2018 Mar 7. PubMed PMID: 29441689.
• Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T. Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy. Neurobiol Dis. 2018 Feb;110:102-121. doi: 10.1016/j.nbd.2017.11.008. Epub 2017 Nov 29. PubMed PMID: 29197620; PubMed Central PMCID: PMC5753797.
• Sharma S, Puttachary S, Thippeswamy A, Kanthasamy AG, Thippeswamy T. Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models. Front Neurol. 2018;9:7. doi: 10.3389/fneur.2018.00007. eCollection 2018. Review. PubMed PMID: 29410648; PubMed Central PMCID: PMC5787145.
• Puttachary S, Sharma S, Verma S, Yang Y, Putra M, Thippeswamy A, Luo D, Thippeswamy T. 1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. Neurobiol Dis. 2016 Sep;93:184-200. doi: 10.1016/j.nbd.2016.05.013. Epub 2016 May 18. PubMed PMID: 27208748.
• Puttachary S, Sharma S, Thippeswamy A, Thippeswamy T. Immediate epileptogenesis: Impact on brain in C57BL/6J mouse kainate model. Front Biosci (Elite Ed). 2016 Jun 1;8(3):390-411. doi: 10.2741/e775. PubMed PMID: 27100347.
• Staunton C, Kumagai K, Thippeswamy T, Djourhi L, Barrette-Jolley R. Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 April; 30(1):1224.35.
• Puttachary S, Sharma S, Tse K, Beamer E, Sexton A, Crutison J, Thippeswamy T. Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry. PLoS One. 2015;10(7):e0131705. doi: 10.1371/journal.pone.0131705. eCollection 2015. PubMed PMID: 26161754; PubMed Central PMCID: PMC4498886.
• Hoffman E, Pickavance L, Thippeswamy T, Beynon RJ, Hurst JL. The male sex pheromone darcin stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in female mice. Front Behav Neurosci. 2015;9:106. doi: 10.3389/fnbeh.2015.00106. eCollection 2015. PubMed PMID: 25972792; PubMed Central PMCID: PMC4413791.
• Staunton CS, Barrett-Jolley R, Djhouri LD, Thippeswamy T. Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an In Vitro Model of Chronic Pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 April; 29(1 SUPPLEMENT):838.1.
• Puttachary S, Sharma S, Stark S, Thippeswamy T. Seizure-induced oxidative stress in temporal lobe epilepsy. Biomed Res Int. 2015;2015:745613. doi: 10.1155/2015/745613. Epub 2015 Jan 20. Review. PubMed PMID: 25650148; PubMed Central PMCID: PMC4306378.
• Tse K, Puttachary S, Beamer E, Sills GJ, Thippeswamy T. Advantages of repeated low dose against single high dose of kainate in C57BL/6J mouse model of status epilepticus: behavioral and electroencephalographic studies. PLoS One. 2014;9(5):e96622. doi: 10.1371/journal.pone.0096622. eCollection 2014. PubMed PMID: 24802808; PubMed Central PMCID: PMC4011859.
• Walker L, Tse K, Ricci E, Thippeswamy T, Sills GJ, White SH, Antoine DJ, Marson A, Pirmohamed M. High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures. The Lancet. Neurology. 2014 February; 383:S105.
• Beamer E, Tse K, Thippeswamy T. Strategies to prevent epileptogenesis: targeting both neuron and glia. Journal of neurochemistry. 2013 May; 125:273-274.
• Beamer E, Otahal J, Sills GJ, Thippeswamy T. N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. Eur J Neurosci. 2012 Nov;36(9):3194-203. doi: 10.1111/j.1460-9568.2012.08234.x. Epub 2012 Sep 4. PubMed PMID: 22943535.
• Bradman MJ, Morris R, McArdle A, Jackson MJ, Thippeswamy T. The effects of L-NAME on neuronal NOS and SOD1 expression in the DRG-spinal cord network of axotomised Thy 1.2 eGFP mice. Neuron Glia Biol. 2011 May;7(2-4):129-41. doi: 10.1017/S1740925X12000051. Epub 2012 May 22. PubMed PMID: 22613021.
• Haddley K, Spencer EM, Vasiliou SA, Howard M, Thippeswamy T, Bubb VJ, Quinn JP. Lithium chloride regulation of the substance P encoding preprotachykinin a, Tac1 gene in rat hippocampal primary cells. J Mol Neurosci. 2011 Oct;45(2):94-100. doi: 10.1007/s12031-010-9431-0. Epub 2010 Aug 6. PubMed PMID: 20690045.
• Cosgrave AS, McKay JS, Thippeswamy T. Differential regulation of vasoactive intestinal peptide (VIP) in the dentate gyrus and hippocampus via the NO-cGMP pathway following kainic acid-induced seizure in the rat. J Mol Neurosci. 2010 Nov;42(3):359-69. doi: 10.1007/s12031-010-9353-x. Epub 2010 Apr 6. PubMed PMID: 20369387.
• Cosgrave AS, McKay JS, Morris R, Quinn JP, Thippeswamy T. The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro. Histol Histopathol. 2010 Jul;25(7):841-56. doi: 10.14670/HH-25.841. PubMed PMID: 20503173.
• Bradman MJ, Arora DK, Morris R, Thippeswamy T. How do the satellite glia cells of the dorsal root ganglia respond to stressed neurons?–nitric oxide saga from embryonic development to axonal injury in adulthood. Neuron Glia Biol. 2010 Feb;6(1):11-7. doi: 10.1017/S1740925X09990494. Epub 2010 Feb 1. PubMed PMID: 20113536.
• Cosgrave AS, McKay JS, Morris R, Quinn JP, Thippeswamy T. Nitric oxide regulates activity-dependent neuroprotective protein (ADNP) in the dentate gyrus of the rodent model of kainic acid-induced seizure. J Mol Neurosci. 2009 Sep;39(1-2):9-21. doi: 10.1007/s12031-008-9169-0. Epub 2009 Jan 7. PubMed PMID: 19130308.
• Cosgrave AS, McKay JS, Bubb V, Morris R, Quinn JP, Thippeswamy T. Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure. Neurobiol Dis. 2008 Jun;30(3):281-292. doi: 10.1016/j.nbd.2008.02.005. Epub 2008 Mar 10. PubMed PMID: 18375135.
• Thippeswamy T, Howard MR, Cosgrave AS, Arora DK, McKay JS, Quinn JP. Nitric oxide-NGF mediated PPTA/SP, ADNP, and VIP expression in the peripheral nervous system. J Mol Neurosci. 2007;33(3):268-77. doi: 10.1007/s12031-007-0066-8. Epub 2007 Sep 11. PubMed PMID: 17952636.
• Thippeswamy T, Haddley K, Corness JD, Howard MR, McKay JS, Beaucourt SM, Pope MD, Murphy D, Morris R, Hökfelt T, Quinn JP. NO-cGMP mediated galanin expression in NGF-deprived or axotomized sensory neurons. J Neurochem. 2007 Feb;100(3):790-801. doi: 10.1111/j.1471-4159.2006.04243.x. PubMed PMID: 17263797.
• Arora DK, Cosgrave AS, Howard MR, Bubb V, Quinn JP, Thippeswamy T. Evidence of postnatal neurogenesis in dorsal root ganglion: role of nitric oxide and neuronal restrictive silencer transcription factor. J Mol Neurosci. 2007;32(2):97-107. doi: 10.1007/s12031-007-0014-7. PubMed PMID: 17873293.
• Thippeswamy T, Cosgrave A, Arora D, Quinn J. NO-cGMP mediated neuropeptides regulation in peripheral nerve injury. Neuropeptides. 2006 December; 40(6):431.